LOCATION:Jianguo Garden Hotel Beijing，No. 17, Jianguomennei Avenue, Beijing
Jung-Bum Shin, Ph.D.
Associate Professor, Department of Neuroscience
University of Virginia
Ph.D., 2003, Free University Berlin,
2003-2009 Postdoctoral Fellow, Oregon Health Science University,
Oregon Hearing Research Center and Vollum Institute
Research focus I: Discovery of novel proteins involved in hearing and deafness
Research focus II: Neurodegeneration and protection of sensory hair cells
Shimon P. Francis, Josh Katz, Kathryn D. Fanning, Kimberly A. Harris, Brian D. Nicholas, Michael M. Lacy, James Pagana, Paul F. Agris and Jung-Bum Shin (2013) A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity, Journal of Neuroscience. 13;33(7):3079-93.
Jung-Bum Shin, Jocelyn F. Krey, Ahmed Hassan, Zoltan Metlagel, Andrew N Tauscher, James M Pagana, Nicholas E. Sherman, Erin D. Jeffery, Kateri J. Spinelli, Hongyu Zhao, Phillip Wilmarth, Dongseok Choi, Larry L. David, Manfred Auer and Peter G. Barr-Gillespie (2013) Molecular architecture of the chick vestibular hair bundle. Nature Neuroscience. 16(3):365-74.
M’hamed Grati, Jung-Bum Shin, Michael D. Weston, James Green, Manzoor A. Bhat, Peter G. Gillespie, and Bechara Kachar (2012) Localization of PDZD7 to the Stereocilia Ankle-Link Associates this Scaffolding Protein with the Usher Syndrome Protein Network. J Neurosci. 2012 Oct 10;32(41):14288-93.
Professor of Developmental NeurobiologyKing’s College, London
Professor Andrea Streit studied Biology at the University of Cologne and obtained her PhD in Neurobiology from the University of Heidelberg, Germany. She trained as a postdoctoral researcher at the University of Turku (Finland), the University of Oxford (UK) and at Columbia University, New York.
Professor Streit joined King’s in 2000, where her research group focuses on the development of vertebrate sense organs. Her primary interest is to understand the molecular and cellular mechanisms that control cell fate decisions in the sensory nervous system, and how we can use this knowledge to promote regeneration and repair. Using multidisciplinary approaches her group studies the signalling and transcription factor networks that control how sensory stem cells diversify into eye, ear and olfactory cells and generate specialised cell types in each organ and how these networks were modulates as complex sense organs emerged during evolution. In addition, Andrea’s group explores the epigenetic mechanisms that control inner ear development and the regeneration of the sensory cells crucial for sound and balance perception.
Apart from leading an international team, Professor Streit is actively involved in PhD student affairs as postgraduate coordinator, mentoring schemes for junior faculty members and postdoctoral researchers, and has held various leadership roles in the Faculty including Dean for Research from 2013 – 2018. She has longstanding expertise in evaluating research quality serving as a member of international advisory boards and of UK research council grant panels.
Sensory nervous system; ear; eye; olfactory epithelium; sensory placodes; gene networks; gene regulation; epigenetic modifications; transcription factors; signalling; regeneration; hair cells
Wei Sun, Ph.D, CCC-A
Associate Professor, Department of Communicative Disorders and Sciences
University at Buffalo
Cellular physiology of spiral ganglion neuron of cochlea
Noise induced central auditory developmental delay
Mechanism of auditory learning
Stem cell physiology
Education / Training:
Ph.D. in Audiology, 2006, The University at Buffalo, Buffalo, New York, USA
M.A. in Audiology, 2006, The University at Buffalo, Buffalo, NY, USA
M.S. in Medicine, 1996, Postgraduate Medical School of PLA, Beijing, China
B.S. in Electronic Technology, 1988, National University of Defense Technology, Changsha, China
Publications in last five years
1. Niu, Y., Kumaraguru, A., Wang, R. and Sun, W. (in press) Hyperexcitability of inferior colliculus neurons caused by acute noise exposure. Journal of Neuroscience Research
2. Sun, W., Niu, Y., Manohar, S., Kumaraguru, A. and Allman, B. (accepted) Early Age Conductive Hearing Loss Impairs Sound Tolerance and Auditory Processing. Canadian Hearing Report
3. Sun, W., Deng, A., Jayaram A. and Gibson B. (2012) Noise Exposure Enhances Auditory Cortex Response and Sound Loudness Perception. Brain Research 1458: 108-116
4. Sun, W., Manohar, S., Jayaram, A., Kumaraguru1, A., Fu, Q., Li, L. and Allman, B. (2011) Early Age Conductive Hearing Loss Impairs Sound Perception Development. Hearing Research 282(1-2): 178-83
Department of Pharmacoloy and Neuroscience, Scholl of Medicine
There are currently no FDA-approved therapies to prevent the hearing loss associated with the usage of cisplatin in chemotherapeutic regimens. We recently demonstrated that the pharmacologic inhibition with kenpaullone or genetic deletion of CDK2 preserved hearing function in animal models treated with cisplatin, which suggests that CDK2 is a promising therapeutic target to prevent cisplatin-induced ototoxicity. In this study, we identified two lead compounds, AT7519 and AZD5438, from a focused library screen of 187 CDK2 inhibitors, performed in an immortalized cell line derived from neonatal mouse cochleae treated with cisplatin. Moreover, we screened 36 analogues of AT7519 and identified analogue 7, which exhibited an improved therapeutic index. When delivered locally, analogue 7 and AZD5438 both provided significant protection against cisplatin-induced ototoxicity in mice. Thus, we have identified two additional compounds that prevent cisplatin-induced ototoxicity in vivo and provided further evidence that CDK2 is a druggable target for treating cisplatin-induced ototoxicity., Journal of Medicinal Chemistry, volume 61(17), 7700-7709, 2018
Abstract for Meeting: Development of Small Molecule Protein Kinase Inhibitors for Hearing Protection (last author), ARO annual Meeting, 42nd ARO Annual Meeting, 44, 2019
Research Rounds ans Seminars at Department of Pharmacology and Neuroscience, 2019
School of Communicative Science and DisordersDalhousie University
Dr. Jian Wang received a master’s degree in physiology in 1989 from the Southeast University of Nanjing, China, where he served as a medical school teacher for several years. He received a master’s degree in audiology in 1998 and a PhD in hearing science in 2000 from the State University of New York at Buffalo. He joined the faculty at the School of Human Communication Disorders in 2001. He teaches basic courses in hearing science and instrumentation for audiology, as well as a seminar in selected topics in audiology.
Dr. Wang’s publications and presentations focus on a variety of topics in hearing science, including: cochlear gene therapy for the prevention of hearing loss due to aging, noise and ototoxic drugs, mechanisms of noise-induced hearing loss, and coding and plasticity in the auditory system induced by hearing loss.
Dr. Wang is currently the principal investigators of three national grants, two from CIHR supporting the research in cochlear gene therapy and relationship between hearing loss and cognitive impairment, and one from NSERC on the physiology of ribbon synapses in cochlea. He is also involved in collaborative research with two institutes in China and holds 3 research grants there as co-PI.
BSc, Physiology, Nanjiing Medical College
MA, Physiology, Southeast University of Nanjing
MA, Audiology, State University of New York at Buffalo PhD, Hearing Sciences, State University of New York at Buffalo
Ototoxicity and noise-induced hearing loss
Cochlear gene therapy
Auditory coding and plasticity
Impact of hearing loss on cognitive function
· O'Leary TP, Shin S, Fertan E, Dingle RN, Almuklass A, Gunn RK, et al. Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease. Genes, brain, and behavior. 2017. DOI: 10.1111/gbb.12370Shi L, Chang Y, Li X, Aiken SJ, Liu L, Wang J. Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem from Incomplete Repair of Ribbon Synapses in the Cochlea. Front Neurosci. 2016;10:231. DOI: 10.3389/fnins.2016.00231
Department of Otolaryngology, University of Kentucky
Skills and Expertise: Deafness, Cochlea, Inner ear
Bio / Education:
Yichang Medical College, Yichang, China
Doctor of Medicine, 1982
Huazhong University of Science & Technology, Wuhan, China
Master of Sciences, 1989
Shanghai Institute of Physiology, Shanghai, China
Doctor of Philosophy (Neuroscience), 1992