LOCATION:Jianguo Garden Hotel Beijing，No. 17, Jianguomennei Avenue, Beijing
Assistant Professor/Project Leader/Key Researcher
The University of Melbourne
A/Prof Gary Rance is the Head of Academic Programs for The University of Melbourne, Department of Audiology and Speech Pathology where he is co-chair of the Research Executive Committee. After completing a Graduate Diploma in Audiology in 1989, Gary undertook a Masters in the field of auditory evoked potentials and then a Doctorate on the diagnosis and management of Auditory Neuropathy in children.
He has continued to work in this area with a specialised interest in auditory evoked potential measurement, assessment of paediatric cochlear implant outcomes and the perceptual characterization of hearing impaired children. Gary regularly undertakes peer-review for a range of national and international journals and also sits on various grant review panels.
Gary is Vice President of the Deafness Foundation and was also a member of the Steering Committee for the Victorian Infant Hearing Screening Program. In February 2008, Gary’s first book “Auditory Steady-State Response Generation, Recording, and Clinical Application” was released internationally. He is also a practicing artist and has been exhibiting his sculptural works for more than 20 years.
XR3.2.5 Amplification Prescribing For Children With ANSD
XR1.2.2 Identification of Long-term Consequences of Middle-ear Infections in Early Childhood
Edward C. and Amy H. Sewall Professor in the School of Medicine
Professor, by courtesy, of Molecular and Cellular Physiology
Otolaryngology - Head& Neck Surgery Divisions
· Professor, Otolaryngology - Head & Neck Surgery Divisions
· Professor (By courtesy), Molecular & Cellular Physiology
· Member, Bio-X
· Member, Wu Tsai Neurosciences Institute
· Director of the Neuroscience Training Program, Stanford University (2013 - Present)
· Director of the Advance Summer Institute, Stanford University (2012 - Present)
Honors & Awards
· Excellence in Diversity and Inclusion, Biosciences (2018)
· Excellence in Diversity and Inclusion, Stanford Biosciences (2014)
· Burt Evans Young Investigator Award, National Organization for Hearing (2002)
· Young Investigator Award, Deafness Research Foundation (1999)
Boards, Advisory Committees, Professional Organizations
· Board of Scientific Councillors, NIDCD (2014 - 2017)
· Postdoc Reviewing Committee, SNI (2017 - Present)
· Graduate student Sustainable funding group, Stanford Medical School (2014 - Present)
· BDAC committee, Stanford Medical School (2015 - Present)
· Nominating Committee, Association for Research in Otolaryngology (2014 - 2015)
· Admissions Committee, Neuroscience training program (2006 - Present)
· Program Committee, Neuroscience Training Program (2010 - Present)
· PhD, Tulane University, Neuroscience (1992)
· BA, Case Western Reserve University, Chemistry (1985)
Anthony Ricci, Alan Cheng, Robert Greenhouse. "United States Patent 61/792,256 Aminoglycoside Antibiotics with Reduced Ototoxicity", Leland Stanford Junior University, Mar 15, 2013
Current Research and Scholarly Interests
The auditory system is a remarkable feat of engineering capable of detecting motion at the atomic level and transmitting this information to the brain with precise timing and fidelity. We use advanced electrophysiologic, imaging, molecular and pharmacologic techniques to probe mechanisms of mechanotransduction and synaptic transmission at the auditory periphery. There are several independent lines of research in the laboratory.
Mechanotransduction, the conversion of mechanical stimulation into an electrical signal, is complex and involves a variety of proteins, many of which have not yet been identified. A major goal of the laboratory is to delineate the functional relevance of mechanotransduction and to identify proteins and their function in this process. To date, we have identified and characterized the tuning properties of the sensory hair bundle and mechanotransducer channels, identifying at least two new physiologically relevant contributions of these channels. We have performed the only single channel study of mechanotransducer channels, demonstrating tonotopic variations in the intrinsic channel properties. We have also performed the only kinetic analysis of activation, again demonstrating tonotopic variations in the kinetics of the mechanotransduction channel. In addition, we have pharmacologically characterized and biophysically mapped the transducer channel pore. Recently we have developed a high speed confocal imaging system that will allow us to optically monitor calcium changes associated with mechanotransduction, allowing us to localize the site of mechanotransduction and directly investigate mechanisms of calcium, regulation.
A second major direction of the laboratory is synaptic transmission where we are interested in identifying mechanisms associated with specializing these synapses to graded and tonic release of transmitter at high rates and with high fidelity. We have morphologically and biophysically characterized these synapses, quantifying release properties at different frequency locations. We are one of only a handful of laboratories who have recorded directly from synaptic terminals where we are investigating mechanisms of multivesicular release. Recently we have developed a technique for measuring vesicular fusion during stimulation so that true release parameters can be investigated. We plan to further develop this technique to be used while measuring membrane potential changes.
A third area of interest for our laboratory is the development of the peripheral system. We are particularly interested in identifying mechanisms associated with the establishment of the tonotopic organization of the cochlea. In addition, indentifying factors that control cell differentiation and specialization, those intrinsic and those extrinsic to the cells is a key priority. This work is critical when trying to repair or replace hair cells either via regenerative or stem cell type therapies.
Although fundamentally a basic science laboratory we have strong ties to translational research both directly and through collaborative efforts. Each of our three major research areas have translationally oriented projects associated with them. In addition, we are developing a project to create a nontoxic aminoglycoside based on biophysical data collected while investigating mechanotransduction.
The auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
Associate Professor of Otolaryngology - Head and Neck Surgery
Associate Professor of Biomedical Engineering
Development of cochlear implants including novel devices based on neural infrared stimulation, use of laser in clinical settings, micromechanics of the cochlea, imaging; Bioengineering; Hearing; Otolaryngology; Physiology
My primary research interests are the development and improvement of cochlear implant electrodes, and the micromechanics of the mammalian cochlea.
The objectives of the current research projects are to investigate the stimulation of (auditory) neurons with optical radiation, to measure the impedances of cochlear structures and possible current paths for the electrically stimulated cochlea. New placements and designs of cochlear implant electrodes are examined. Furthermore, mechanical properties, such as stiffness and mass of cochlear structures are examined in normal and developing animals. Currently a novel technique is developed to visualize soft tissue structures without opening the bony cochlear wall.
Funding is provided by the National Institute of Health (NIH) and the E.R. Capita Foundation to study the stimulation of neurons using optical radiation and by the National Science Foundation (NSF) for cochlear micromechanics.
Optical stimulation of auditory neurons: effects of acute
and chronic deafening.
Richter CP, Bayon R, Izzo AD, Otting M, Suh E, Goyal S, Hotaling J, Walsh JT
Hearing research 2008 Aug; 242(1-2):42-51
Laser stimulation of auditory neurons: effect of shorter
pulse duration and penetration depth.
Izzo AD, Walsh JT, Ralph H, Webb J, Bendett M, Wells J, Richter CP
Biophysical journal 2008 Apr 15; 94(8):3159-66
Developmental changes of mechanics measured in the gerbil
Emadi G, Richter CP
Journal of the Association for Research in Otolaryngology : JARO 2008 Mar; 9(1):22-32
Tectorial membrane stiffness gradients.
Richter CP, Emadi G, Getnick G, Quesnel A, Dallos P
Biophysical journal 2007 Sep 15; 93(6):2265-76
Joseph Santos-Sacchi, PhD
Professor of Surgery (Otolaryngology), of Cellular and Molecular Physiology and of Neuroscience
School of Medicine
Dr. Joseph Santos-Sacchi, Professor, works on understanding how outer hair cells (OHC) help us hear so well. His lab focuses on electrophysiological assessment of hair cell function and molecular manipulations of the proteins that are important for hearing.
EDUCATION & TRAINING
Columbia University, Audiology (1978)
Columbia University (1978)
Columbia College, Psychology (1973)
HONORS & RECOGNITION
Master of Arts, Honoris Cuasa Yale University, New Haven, CT (1995)
Hair Cells, Auditory; Ear, Inner; Neurosciences; Otolaryngology; Physiology
The exquisite sensitivity and frequency resolving power of the mammalian inner ear depends upon interactions between the two receptor cells of the organ of Corti, inner (IHC) and outer (OHC) hair cells. While inner hair cells appear to function solely as receptors of acoustic information, OHC’s function both as receptors and effectors, producing motile responses as a function of transmembrane potential fluctuations.
These motile responses modify the mechanical input to the inner hair cells which receive the majority of afferent innervation, thereby enhancing the gross frequency tuning afforded by basilar membrane mechanics. Dr. Joseph Santos-Sacchi studies the effector role of the OHC with electrophysiological (patch clamp) and displacement measurement techniques using isolated OHCs from the guinea pig. He also works on the motor protein (prestin) responsible for the cells’ mechanical activity, utilizing mutational analysis and expression systems to understand how it works.
Specialized Terms: Mammalian inner ear
Clinical Assistant ProfessorUniversity at Buffalo
One of the drawbacks to modern society is our more frequent exposure to noisy environments. This can make daily communicative tasks difficult, especially for those with hearing impairment, but it may also result in a cascade of changes throughout the auditory system. The auditory system has proven to be remarkably plastic, leading to the notion that our frequent exposure to “non-traumatic” noise could result in impaired auditory function. In contrast, employing noise to induce plastic changes within the auditory system could potentially result in more effective management options for hearing disorders such as tinnitus and hyperacusis. One of my primary research interests lie in exploring auditory plasticity associated with extended exposure to low or moderate levels of noise. Specifically, how these changes could negatively impact hearing ability, or could be leveraged to aid in the management of tinnitus or hyperacusis.
Clinically, I have experience in diagnostic audiology, hearing aid evaluations and programming, real-ear measures, tinnitus evaluations and management, electrophysiology testing, and clinical research. One of my professional goals is to aid in bridging the gap between scientific research and clinical practice.
Employment/ Professional Experience