会议通知

ANNOUNCEMENT

会议摘要 REMARK

会议时间:2019年9月20日-22日

TIME:SEP.20-22,2019

地址:北京好苑建国酒店,北京市建国门内大街17号

LOCATION:Jianguo Garden Hotel Beijing,No. 17, Jianguomennei Avenue, Beijing

邮箱:chrc2019@sina.com.cn

E-MAIL:chrc2019@sina.com.cn

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国际讲者集锦-第二期

    Patrick Kanold

    Professor, Department of  Biology

    University of Maryland  

 


   

Education  

Dipl. Ing (g (M.Sc.), Technische Universität Berlin, Germany, 1994  

Ph.D., Johns Hopkins University, 2000  

PostDoc, Harvard Medical School 2000-2005  

Instructor, Harvard Medical School 2005-2006  

Awards

2007 Ralph E Powe Award

2010 Alfred P. Sloan Foundation

2013 NOHR/ARo Burt Evans Award

Research Interests  

Dr. Kanold studies the development and plasticity of the brain, in particular how periods of learning and plasticity are initiated and controlled. His work focuses on the development of the central auditory and visual system in particular on the role of early cortical circuits in brain wiring. He uses advanced neurophysiological, in vivo imaging, optogenetic, molecular and computational techniques. His work furthers our understanding of how prenatal and postnatal brain injury contribute to neurodevelopmental disorders such as cerebral palsy, epilepsy and schizophrenia.

Recent Publications

 P.O. Kanold, “Subplate neurons: crucial regulators of cortical development and plasticity”, Frontiers in Neuroanatomy, 3:16. 2009

A. Datwani, M.J. McConnell, P.O. Kanold, K.D. Micheva, B. Busse, M. Shamloo, S.J. Smith, and C.J. Shatz,, “Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity”, Neuron, 64: 463–470, 2009

P.O. Kanold, Y.A. Kim, T. GrandPre, C. J. Shatz, "Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice”, J. Physiology (London), 587(Pt 12):2857-67. 2009

...


    Hongzhe Li 

    Associate Professor

    Department of Otolaryngology and Head & Neck Surgery

    Loma Linda University

   


 

Employment Research Experience

2015 – Present, VA Loma Linda Healthcare System/ Loma Linda University

Position: Research Scientist/ Assistant Professor

2013 – 2015, Oregon Health and Science University

Position: Assistant Scientist (Oregon Hearing Research Center)

2008 – 2013, Oregon Health and Science University

Position: Senior Research Associate

2004 – 2008 Fred Hutchinson Cancer Research: Seattle, WA

Position: Senior Fellow (Clinical Research Division)

2004 – 2008 University of Washington School of Medicine: Seattle, WA

Position: Senior Fellow (Radiation Oncology and Immunology)

Sep 2003- Sep 2004 Arizona State University: Tempe, AZ

Position: Research Associate (Neural Coding Lab/Speech and Hearing Science)

Education

PhD in Neurophysiology, Arizona State University, 1997 -2003

BS in Life Science, Peking University, 1992, 1997


    LU, Xiaowei

    Associate Professor, Cell Biology

    University of Virgina

 



Education

•        BS, Biochemistry, Beijing University

•        PhD, Biology, Massachusetts Institute of Technology

•        Postdoc, Developmental Neurobiology, University of California, San Francisco

Research Interests

Developmental regulation of planar cell polarity in the mammalian nervous system

Research Description

Cell polarity is tightly coupled to specialized cell functions and is fundamental to many cellular processes in development and disease. Two forms of epithelial polarity have been observed: one along the apical-basal axis, and one orthogonal to the apical-basal axis known as planar cell polarity (PCP). The Lu lab is interested in dissecting the signaling events that generate planar asymmetry and the resulting cellular behaviors during mammalian development, with a specific focus on two types of polarized cells in the nervous system, namely neuroepithelial cells and neurons.

It has been shown that an evolutionarily conserved noncanonical, b-catenin-independent Wnt pathway regulates PCP and is involved in diverse processes such as neural tube closure and cochlear hair cell morphogenesis. Recently, in a gene trap screen in the mouse, we identified PTK7, an atypical receptor tyrosine kinase, as a novel regulator of PCP in vertebrates. Interestingly, homologs of several vertebrate PCP genes, including PTK7, have not been implicated in PCP signaling in Drosophila, suggesting that vertebrates have evolved novel strategies to regulate PCP. Using PTK7 as an entry point, we are taking a combination of biochemical, genetic and cell biological approaches to further elucidate signaling mechanisms by which the PCP pathway exert its effect on cellular machinery, such as the cytoskeleton and protein trafficking network.

The cochlear sensory epithelium of the mouse offers an attractive system to study PCP at a single cell resolution both in vivo and in organotypic cultures. PCP is manifested by the asymmetric orientation of the hair cell stereocilia, an actin-rich structure responsible of mechanotransduction. Using a variety of genetic and molecular manipulations and imaging techniques, experiments are underway to better understand the sequence of events that lead to coordinated polarized outgrowth of stereocilia across the sensory epithelium.

We are extending our analysis of the PCP pathway into the development of the central nervous system. Our preliminary analysis of mutant phenotype suggests that PCP pathway is involved in patterning certain regions of the CNS. Currently we are investigating the molecular pathway that underlies the patterning defect. Furthermore, aided by expression studies, we hypothesize that PCP signaling also functions in later aspects of CNS development, such as cell and axon migration and target selection. We plan to use transgenic mice and in vitro neuronal cultures to test this hypothesis.

Ultimately, we hope that our studies will shed light on how the versatile PCP pathway controls cell polarity in different contexts during normal development and how mutations disrupt polarity in related human disease and birth defects

Selected Publications

Andreeva A, Lee J, Lohia M, Wu X, Macara IG, Lu X, PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity., 2014; Developmental cell. 29(1) 20-33. PMID: 24703874 | PMCID: PMC4086913

Williams M, Yen W, Lu X, Sutherland A, Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate., 2014; Developmental cell. 29(1) 34-46. PMID: 24703875 | PMCID: PMC4120093

Sipe CW, Liu L, Lee J, Grimsley-Myers C, Lu X, Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization., 2013; Development (Cambridge, England). 140(8) 1785-95. PMID: 23533177 | PMCID: PMC3621493

Lee J, Andreeva A, Sipe CW, Liu L, Cheng A, Lu X, PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium., 2012; Current biology : CB. 22(11) 956-66. PMID: 22560610 | PMCID: PMC3407606

Sipe CW, Lu X, Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms., 2011; Development (Cambridge, England). 138(16) 3441-9. PMID: 21752934 | PMCID: PMC3143564

Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN, The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear., 2010; BMC developmental biology. 10() 87. PMID: 20704721 | PMCID: PMC2930600

...


 

   Tobias Moser

    Professor of Auditory Neuroscience

    Institute for Auditory Neuroscience & InnerEarLab

    University Medical Center Göttingen



1995 M.D. University of Jena

1994 - 1997 Postdoc with E. Neher at the MPI for Biophysical Chemistry

1997-2001 Junior Group Leader at the at the MPI for Biophysical Chemistry, Göttingen

since 2001 Leader of the InnerEarLab and Clinical Work at the Department of Otolaryngology, University Medical Center Göttingen

Director of the Institute for Auditory Neuroscience, University Medical Center Göttingen and group leader at the MPIs for Experimental Medicine and Biophysical Chemistry and the German Primate Center

Major Research Interests

Auditory Neuroscience - Synaptic Physiology and Pathophysiology - Audiology and Neuroprosthetics


Our work focuses on the molecular anatomy, physiology and pathophysiology of sound encoding and information processing in the auditory system as well as the restoration of hearing by gene replacement therapy and optogenetic stimulation. We combine various techniques to characterize synapses of hair cells and the auditory brainstem from the molecular to the systems level. This way we have contributed to the understanding of structure and function of auditory synapses and initiated the concept of auditory synaptopathy. Towards restoration of hearing we aim to establish virus-mediated gene replacement therapy of auditory synaptopathy and pursue the optogenetic stimulation of auditory nerve for improving the performance of the cochlear implant. 

Selected Recent Publications

  • Wrobel C, Dieter A, Huet A, Keppeler D, Duque-Afonso C, Vogl C, Hoch G, Jeschke M, Moser T (2018) Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils. Jul 11;10(449). pii: eaao0540
  • Neef J, Ohn TL, Urban NT, Frank T, Jean P, Hell SW, Willig KI, Moser T (2018) Quantitative optical nanophysiology of Ca2+-signaling at inner hair cell active zones. Nat commun, 18;9(1):290. doi: 10.1038/s41467-017-02612-y.
  • Mager T, Lopez de la Morena D, Senn V4,5, Schlotte J, D Errico A, Feldbauer K, Wrobel C, Jung S, Bodensiek K, Rankovic V, Browne L, Huet A, Jüttner J1, Wood PG, Letzkus JJ, Moser T, Bamberg E (2018) High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics. Nat Commun. 2018 May 1;9(1):1750. doi: 10.1038/s41467-018-04146-3...

     Anthony Wei Peng

     Assistant Professor

     Department SOM - Physiology

     University of Colorado Denver - Anschutz Medical Campus

  


Research activities and funding    

1.      F31DC009168 (PENG, ANTHONY WEI) ,Sep 1, 2007 - Aug 31, 2008, NIH/NIDCD, Inner Ear Hair Bundle Proteomics, Role: Principal Investigator

2.      F32DC010975 (PENG, ANTHONY WEI), May 1, 2010 - Apr 30, 2013,NIH/NIDCD, Second messenger regulation of hair cell mechanotransduction, Role: Principal Investigator  

3.      K99DC013299 (PENG, ANTHONY WEI),Jul 1, 2013 - Jun 30, 2015, NIH/NIDCD, Molecular roles in active and passive mechanics in cochlear hair bundles, Role: Principal Investigator   

4.      R00DC013299 (PENG, ANTHONY WEI),Aug 1, 2015 - Jul 31, 2018,NIH/NIDCD, Molecular roles in active and passive mechanics in cochlear hair bundles, Role: Principal Investigator   

5.      R01DC016868 (PENG, ANTHONY WEI), Jun 7, 2018 - May 31, 2023, NIH/NIDCD, Molecular mechanisms of cochlear hair bundle mechanics, Role: Principal Investigator     

Selected publications

1.      Effertz T, Becker L, Peng AW, Ricci AJ. Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation. J Neurosci. 2017 11 29; 37(48):11632-11646. PMID: 29066559.

2.      Kazmierczak M, Kazmierczak P, Peng AW, Harris SL, Shah P, Puel JL, Lenoir M, Franco SJ, Schwander M. Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. J Neurosci. 2017 03 29; 37(13):3447-3464. PMID: 28209736.

3.      Peng AW, Gnanasambandam R, Sachs F, Ricci AJ. Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer. J Neurosci. 2016 Mar 09; 36(10):2945-56. PMID: 26961949.

4.      Peng AW, Ricci AJ. Glass Probe Stimulation of Hair Cell Stereocilia. Methods Mol Biol. 2016; 1427:487-500. PMID: 27259944.

5.      Nam JH, Peng AW, Ricci AJ. Underestimated sensitivity of mammalian cochlear hair cells due to splay between stereociliary columns. Biophys J. 2015 Jun 02; 108(11):2633-47. PMID: 26039165.

6.      Peng AW, Effertz T, Ricci AJ. Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry. Neuron. 2013 Nov 20; 80(4):960-72. PMID: 24267652.

7.      Doll JC, Peng AW, Ricci AJ, Pruitt BL. Faster than the speed of hearing: nanomechanical force probes enable the electromechanical observation of cochlear hair cells. Nano Lett. 2012 Dec 12; 12(12):6107-11. PMID: 23181721.

8.      Castellano-Muñoz M, Peng AW, Salles FT, Ricci AJ. Swept field laser confocal microscopy for enhanced spatial and temporal resolution in live-cell imaging. Microsc Microanal. 2012 Aug; 18(4):753-60. PMID: 22831554.

9.      Peng AW, Salles FT, Pan B, Ricci AJ. Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction. Nat Commun. 2011 Nov 01; 2:523. PMID: 22045002.

10.   Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell. 2010 May 14; 141(4):704-16. PMID: 20478259.

11.   Peng AW, Ricci AJ. Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification? Hear Res. 2011 Mar; 273(1-2):109-22. PMID: 20430075.

12.   Peng AW, Belyantseva IA, Hsu PD, Friedman TB, Heller S. Twinfilin 2 regulates actin filament lengths in cochlear stereocilia. J Neurosci. 2009 Dec 02; 29(48):15083-8. PMID: 19955359.

13.   Xu Z, Peng AW, Oshima K, Heller S. MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. J Neurosci. 2008 Oct 29; 28(44):11269-76. PMID: 18971469.

...


 

    David W. Raible

    Professor of Biological Structure 

    Adjunct Professor of Genome Sciences and of Biology

    University of Washington

      

 

RESEARCH FOCUS:  Development of sensory structures in the zebrafish

LATERAL LINE

The lateral line is a placode-derived structure used by acquatic vertebrates to detect water flow. It consists of groups of mechanosensory hair cells clustered into neuromasts on the surface of the animal.

We are interested in how neuromasts are initially positioned in the head and body, and how new neuromasts are formed as the animal grows.

SENSORY HAIR CELL DEATH AND REGENERATION

Zebrafish mechanosensory hair cells are susceptible to environmental insult resulting in death, just as are those in the mammalian inner ear. 

We are using the genetics of the zebrafish to identify modifiers of hair cell death.  In addition, we are studying how new hair cells regenerate after damage.

PUBLICATIONS

Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells.

Hailey DW, Esterberg R, Linbo TH, Rubel EW, Raible DW

The Journal of clinical investigation. 2017 Feb; 127 2: 472-486

Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.

Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW

The Journal of clinical investigation. 2016 09; 126 9: 3556-66

Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells.

Suli A, Pujol R, Cunningham DE, Hailey DW, Prendergast A, Rubel EW, Raible DW

Journal of cell science. 2016 06; 129 11: 2250-60

Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance.

Cruz IA, Kappedal R, Mackenzie SM, Hailey DW, Hoffman TL, Schilling TF, Raible DW

Developmental biology. 2015 Jun; 402 2: 229-38

There and back again: development and regeneration of the zebrafish lateral line system.

Thomas ED, Cruz IA, Hailey DW, Raible DW

Wiley interdisciplinary reviews. Developmental biology. ; 4 1: 1-16

...